Irrigation water salinity is one of the most important challenges in agriculture. The purpose of this study was to evaluate the yield and yield of peanut varieties under irrigation and salinity conditions. The present two years study was carried out in a split plot based on randomized complete block design with three replications in Guilan province. The main factor was irrigation with 40, 60, 80 and 100% water requirement and sub-treatment was including salinity of 1, 3, 5 and 7 dS/m and sub-treatment was including four peanut cultivars (‘Guil’, ‘Gorgani’, ‘Jonobi’ and ‘Mesri’). The highest seed yield was obtained in ‘Jonobi’ cultivar with 1 dS/m salinity and ‘Guil’ cultivar with 5 dS/m was 1254 and 1127 kg/ha respectively. The effect of irrigation on cultivars showed that the highest amount of seed yield in ‘Guill’ cultivar in both years, in condition of 80% water requirement was 1483 and 1347 kg/ha respectively. The highest seed yield in cultivar and in 100% water requirement and 1 dS/m salinity in both year was 1883 and 1710 kg/ha, respectively. According to the results, ‘Guil’ cultivar is the most suitable cultivar for cultivation of the study area.